For more information on the possible side effects of methadone, or tips on how to deal with a troubling side effect, talk with your doctor or pharmacist.

Methadone should be given with caution and the initial dose reduced rein certain patients, such as the elderly and debilitated and those with severe impairment of hepatic or renal function, hypothyroidism, Addison's disease, prostatic hypertrophy, or urethral stricture.

Pharmacodynamic interactions may occur with concomitant use of methadone and potentially arrhythmogenic agents such as class I and III antiarrhythmics, some neuroleptics and tricyclic antidepressants, and calcium channel blockers.

Orthostatic hypotension (low blood pressure when getting up after sitting or lying down). Symptoms can include:

Switching a patient from another chronically administered opioid to methadone requires caution due to the uncertainty of dose conversion ratios and incomplete cross-tolerance. Deaths have occurred in opioid tolerant patients during conversion to methadone. Conversion ratios rein many commonly used equianalgesic dosing tables do not apply in the Umgebung of repeated methadone dosing.

The physician should not confuse such symptoms with those of narcotic abstinence and should not attempt to treat anxiety by increasing the dose of methadone. The action of methadone hinein maintenance treatment is limited to the control of narcotic withdrawal symptoms and is ineffective for relief of general anxiety.

The content in this section is aimed at anyone involved rein planning, implementing or making decisions about health and social responses.

Hepatic Impairment – Methadone has not been extensively evaluated rein patients with hepatic insufficiency. Methadone is metabolized by hepatic pathways, therefore patients with liver impairment may Beryllium at risk of accumulating methadone after multiple dosing.

Opioid antagonists should not be administered hinein the absence of clinically significant respiratory or cardiovascular depression. Hinein an individual physically dependent on opioids, the administration of the usual dose of an opioid antagonist may precipitate an acute withdrawal syndrome.

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Certified treatment programs shall dispense and use methadone in oral form only and according to the treatment Erhaltungstherapie mit Methadontabletten requirements stipulated rein the Federal Opioid Treatment Standards (42 CFR 8.12). See below for important regulatory exceptions to the general requirement for certification to provide opioid agonist treatment.

The safety and effectiveness of this drug hasn’t been established rein children. It shouldn’t be used rein children younger than 18 years.

Urine acidification has been shown to increase renal elimination of methadone. Forced diuresis, peritoneal dialysis, hemodialysis, or charcoal hemoperfusion have not been established as beneficial for increasing the elimination of methadone or its metabolites.

Narcotics with mixed agonist-antagonist properties should not be used for pain control during Laboratorium hinein patients chronically treated with methadone as they may precipitate acute withdrawal.